Rapid Bioprocess Prototyping Centre

The RBPC houses the most advanced technology to rigorously assess the potential of new cell lines, bio-products or novel approaches to bioprocessing. The facility is focused around the bioprocess stages up to an industrially compatible scale (15 litres STR reactors) and has the facilities to address the following:

  • Phenotypic Micro-Arrays. High throughput culture systems where a broad picture of the construct’s metabolism can be rapidly gained to guide the next culture stage
  • Mini-scale parallel processing via multiple 1 litre scale STR reactors
  • Transfer to industrially compatible scale and process design space validation via fermentanomics (metabolomics analysis of scaled fermentation processes)
  • Bioprocess model including scale-up criteria
See below for details of the equipment available.



Booking

Booking enquiries should be directed to: rapidbio@ibioic.com
See details below for information on the equipment available within this centre.

Did you know that we also have a Flexible Downstream Bioprocessing Centre at Heriot Watt University? Find out more.

FlexBio

Complementary to the RBPC, FlexBio focuses on scale-ready process development, lowering the cost of process development and providing a feed into facilities such as the Centre for Process Innovation as a final demonstration of proof at scale.


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Omnilog Phenotype Microarray System

A proprietary technology that can quantitatively evaluate thousands of phenotypes in microbial cell assays at any one time.

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Applikon 15L Biobench Fermenter System

A stainless steel reactor with a steam-in-place steralisation system. The system can be used for scale-up studies, medium and process optimisation, batch, fed batch, perfusion and continuous clutivation. The RBPC has two systems available.

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Kaiser RXN2 Raman Spectrometer with MR filtered probe

This system allows for flexible sampling of both solids and liquids. The RXN2 is a multi-channel analyser with spectral coverage of +150 to +3425cm-1 and spectral resolution to 4 cm-1. The MR filtered probe is versatile, for noth at-line and in-line analysis.

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Agilent 1290 UHPLC

An adaptive system that can handle a wide range of chromatography applications. The system comes with an auto-sampler and a Refractive Index Detector and Diode-Array Detector, along with ChemStation software for efficient reviewing and analysis of results.

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YSI 2900 Biochemistry Analyser

The Gold Standard in bio-analytical instruments allowing for highly accurate and quick results in a wide range of different chemistries including:

  • Glucose
  • Ammonium
  • Xylose
  • Lactate
  • Sucrose
  • Choline
  • Glutamine
  • Galactose
  • Ethanol
  • Glutamate
  • Lactose
  • Hydrogen Peroxide
  • Methanol
  • Glycerol
 








DASGIP 8 x Parallel Bioreactor System

A multi-reactor system that allows advanced bioprocess control and automation in cell culture and microbiology. With the use of up to eight reaction vessels the system allows parallel processing control of parameters, user-defined profiles and innumerable automation results in accelerated and efficient process development. The DASware software solutions support DoE, process historians and comprehensive data management.





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